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doi:10.1016/j.jaci.2013.11.030 Siddiqui S, Engel N, Gabriel S, et al

For example, the deletion of tumor suppressor genes, such as PTEN and P53 or the activation of tumor genes, such as c-Myc and Ras, may induce changes in nutrient supply, metabolic enzymes, metabolic requirements and many other metabolic characteristics